A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT

The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smal...

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Bibliographic Details
Published inExperimental physiology Vol. 74; no. 6; pp. 947 - 950
Main Authors Leach, Richard M., Twort, Charles H. C., Cameron, Ian R., Ward, Jeremy P. T.
Format Journal Article
LanguageEnglish
Published England The Physiological Society 12.11.1989
Subjects
Animals
Male
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth, Vascular - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Rats
Serotonin - pharmacology
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Summary:The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (〈100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.
ISSN:0958-0670
0144-8757
1469-445X
DOI:10.1113/expphysiol.1989.sp003366