Multifocal occurrence of gastric carcinoma in patients with a family history of gastric carcinoma

• Published in: Cancer Vol. 83; no. 7; pp. 1307 - 1311
• Main Authors: Morita, Masaru, Kuwano, Hiroyuki, Baba, Hideo, Taketomi, Akinobu, Kohnoe, Shunji, Tomoda, Hirotsugu, Araki, Kohshi, Saeki, Hiroshi, Kitamura, Kaoru, Sugimachi, Keizo
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.10.1998; Wiley-Liss
• Subjects: Alcohol Drinking - adverse effects; Biological and medical sciences; drinking; family history; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Medical sciences; Middle Aged; multiple gastric carcinoma; Neoplasms, Multiple Primary - genetics; Odds Ratio; risk factor; Risk Factors; smoking; Smoking - adverse effects; Stomach; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Asia; Japan; Human; Stomach; Carcinoma; Ethanol; Tobacco smoking; Malignant tumor; Epidemiology; Alcoholic beverage; Family story; Risk factor; Digestive diseases; Public health; Antecedent; Gastric disease
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1307::AID-CNCR6>3.0.CO;2-F

BACKGROUND Smoking and alcoholic beverage drinking habits as well as a family history of cancer are well known risk factors for the multifocal occurrence of squamous cell carcinoma of the esophagus and the head and neck region. However, the role of these risk factors in multiple gastric carcinoma remains to be clarified. The purpose of this study was to examine the risk factors for multiple gastric carcinoma. METHODS The smoking and drinking habits as well as the family history of 157 patients with synchronous multiple gastric carcinoma and 157 patients with solitary gastric carcinoma who were similar with regard to gender, age, stage of the tumor, and year of admission were investigated. The risk of a multiple occurrence of gastric carcinoma also was elevated using the odds ratio (OR). RESULTS The ORs of a multifocal occurrence of gastric carcinoma in patients who currently smoked and drank alcoholic beverages were 1.1 and 0.8, respectively, although the ORs were not related to the quantity of smoking or drinking. In patients with a close relative with gastric carcinoma the OR was 2.1 (95% confidence interval [CI], 1.3‐3.7). In those patients with ≥2 close relatives with gastric carcinoma, the OR increased to 5.1 (95% CI, 1.2‐21.1). Conversely, no significant elevation in the ORs was recognized regarding a family history of other cancers. CONCLUSIONS In this study, a family history of gastric carcinoma was found to be clearly associated with the multifocal occurrence of gastric carcinoma; however, no significant correlation between the multifocal occurrence of gastric carcinoma in these patients and their smoking and drinking habits was recognized. Cancer 1998;83:1307‐1311. © 1998 American Cancer Society. In patients with gastric carcinoma, a family history of gastric carcinoma is a risk factor for the multifocal occurrence of their gastric carcinoma.