ACTION OF CHLOROTHIAZIDE ON THE DISTRIBUTION, EXCRETION AND HYPOTENSIVE EFFECT OF PEMPIDINE IN MAN

When chlorothiazide is given to hypertensive patients who are receiving pempidine a rise in plasma pempidine concentration occurs and this is proportionately greater than the additional fall in blood pressure. After pempidine has been added to human whole blood in vitro or in vivo the ratio of the p...

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Published inBritish Journal of Pharmacology and Chemotherapy Vol. 17; no. 3; pp. 488 - 506
Main Authors DOLLERY, C. T., EMSLIE‐SMITH, D., MUGGLETON, D. F.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.12.1961
Subjects
Antihypertensive Agents - pharmacology
Blood Pressure
Body Fluids
Chlorothiazide - pharmacology
Erythrocytes
Humans
Hypertension
Hypotension
Male
Old Medline
Pempidine
Piperidines - pharmacology
CHLOROTHIAZIDE/pharmacology
PIPERIDINES/pharmacology
ANTIHYPERTENSIVE AGENTS/pharmacology
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Summary:When chlorothiazide is given to hypertensive patients who are receiving pempidine a rise in plasma pempidine concentration occurs and this is proportionately greater than the additional fall in blood pressure. After pempidine has been added to human whole blood in vitro or in vivo the ratio of the pempidine concentration in the red cells to that in the plasma falls in the course of 1 hr from an initial value greater than 2 to about 1.2. If chlorothiazide is present also, however, the ratio remains constant at 0.7. Changes in the plasma pempidine concentration in vivo probably result from the binding of pempidine to plasma protein in the presence of chlorothiazide. This has been observed in vitro by a dialysis technique.
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ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1961.tb01136.x