Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study

• Published in: Alzheimer's & dementia Vol. 20; no. 7; pp. 4486 - 4498
• Main Authors: Yerramalla, Manasa Shanta, Darin‐Mattsson, Alexander, Udeh‐Momoh, Chinedu T, Holleman, Jasper, Kåreholt, Ingemar, Aspö, Malin, Hagman, Göran, Kivipelto, Miia, Solomon, Alina, Marseglia, Anna, Sindi, Shireen
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.07.2024
• Subjects: Aged; Alzheimer Disease; amyloid beta; Biomarkers; cerebrospinal fluid biomarkers; cognitive performance; cognitive reserve; Cognitive Reserve - physiology; Cross-Sectional Studies; Female; Humans; Hydrocortisone - analysis; Hydrocortisone - metabolism; Male; Medicin och hälsovetenskap; memory clinic; Middle Aged; Neuropsychological Tests - statistics & numerical data; perceived stress; phosphorylated tau; Saliva - chemistry; salivary cortisol; tau Proteins; total tau; cerebrospinal fluid biomarkers; total tau; cognitive reserve; perceived stress; salivary cortisol; cognitive performance; memory clinic; amyloid beta; phosphorylated tau
• ISSN: 1552-5260; 1552-5279; 1552-5279
• DOI: 10.1002/alz.13866

INTRODUCTION Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation. METHODS We examined cross‐sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD‐related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3‐year follow‐up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol. RESULTS Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial association of CRI on cognition. A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio. No association was found between CRI and AD‐related biomarkers. DISCUSSION Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients. Highlights Physiological stress may reduce the neurocognitive benefits accrued from cognitively stimulating and enriching life experiences (cognitive reserve [CR]) in memory clinic patients. Cortisol awakening response modified the relation between CR and P‐tau181, a marker of Alzheimer's disease (AD). Effective stress management techniques for AD and related dementia prevention are warranted.