Cardiovascular instability following bolus dose of etomidate

A patient with alveolar proteinosis developed unexpected cardiovascular instability after broncho-alveolar lavage. He had received two bolus doses of etomidate within an 18-hour period. Serum cortisol concentrations were low and hydrocortisone replacement therapy was necessary to restore arterial pr...

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Bibliographic Details
Published inAnaesthesia Vol. 44; no. 5; p. 404
Main Authors McGrady, E M, Wright, I H
Format Journal Article
LanguageEnglish
Published England 01.05.1989
Subjects
Anesthesia, Intravenous - adverse effects
Etomidate - administration & dosage
Etomidate - adverse effects
Humans
Hydrocortisone - blood
Hypotension - blood
Hypotension - chemically induced
Male
Middle Aged
Postoperative Complications
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Summary:A patient with alveolar proteinosis developed unexpected cardiovascular instability after broncho-alveolar lavage. He had received two bolus doses of etomidate within an 18-hour period. Serum cortisol concentrations were low and hydrocortisone replacement therapy was necessary to restore arterial pressure. Implications for management of critically ill patients who receive bolus doses of etomidate are discussed.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1989.tb11339.x