Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes

The interaction between the vulnerable atherosclerotic plaque prone to disruption and thrombus formation is the cornerstone of acute coronary syndrome (ACS). Although distinct from one another, the atherosclerotic and thrombotic processes appear to be interdependent, hence the term atherothrombosis....

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Published inJournal of thrombosis and haemostasis Vol. 1; no. 7; pp. 1410 - 1421
Main Authors Fuster, V., Corti, R., Fayad, Z. A., Schwitter, J., Badimon, J. J.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Inc 01.07.2003
Subjects
acute coronary syndromes
Animals
Arteriosclerosis
Endothelium, Vascular - pathology
Female
Heart - anatomy & histology
Heart Diseases - diagnosis
Heart Diseases - pathology
Humans
Inflammation
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Models, Biological
Monocytes - metabolism
Myocardium - pathology
thrombosis
vascular biology
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Summary:The interaction between the vulnerable atherosclerotic plaque prone to disruption and thrombus formation is the cornerstone of acute coronary syndrome (ACS). Although distinct from one another, the atherosclerotic and thrombotic processes appear to be interdependent, hence the term atherothrombosis. Inflammation is a crucial common pathophysiological mechanism. Overall, the association of plaque vulnerability and ACS has been well documented. Given the multifactorial origin of atherothrombosis the best preventive approach should be aggressive management of all the risk factors. New interventions should be directed toward decreasing vulnerability of the lesions thereby decreasing the risk of ACS.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1046/j.1538-7836.2003.00271.x