High‐Dose Isoflavones Do Not Improve Metabolic and Inflammatory Parameters in Androgen‐Deprived Men With Prostate Cancer

• Published in: Journal of andrology Vol. 32; no. 1; pp. 40 - 48
• Main Authors: Napora, Joshua K., Short, Ryan G., Muller, Denis C., Carlson, Olga D., Odetunde, Juliana O., Xu, Xiaoqiang, Carducci, Michael, Travison, Thomas G., Maggio, Marcello, Egan, Josephine M., Basaria, Shehzad
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2011; American Society of Andrology
• Subjects: Aged; Androgen Antagonists - therapeutic use; Androgen deprivation; Androgens - deficiency; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Glucose - metabolism; Gynecology. Andrology. Obstetrics; Humans; inflammation; Inflammation - metabolism; Insulin Resistance; Isoflavones - administration & dosage; Male; Male genital diseases; Mammalian male genital system; Medical sciences; Metabolic diseases; metabolic syndrome; Metabolism - drug effects; Miscellaneous; Nephrology. Urinary tract diseases; Other metabolic disorders; Pilot Projects; Prostatic Neoplasms - drug therapy; Soybean Proteins - therapeutic use; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Vertebrates: reproduction; Endocrinopathy; Human; Urinary system disease; Prostate disease; Metabolic diseases; Cardiovascular disease; Male; Inflammation; Malignant tumor; Metabolic syndrome; Male genital system; Reproduction; Androgen deprivation; Male genital diseases; Prostate cancer; Cancer
• ISSN: 0196-3635; 1939-4640
• DOI: 10.2164/jandrol.110.010983

The profound hypogonadism that occurs with androgen deprivation therapy (ADT) for prostate cancer (PCa) results in complications such as diabetes and metabolic syndrome that predispose to cardiovascular disease. Because phytoestrogens have been associated with an improvement in metabolic parameters, we evaluated their role in men undergoing ADT. Our objective was to evaluate the effects of high‐dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT. This was a randomized, double‐blind, placebo‐controlled, 12‐week pilot study. Participants were randomly assigned to receive 20 g of soy protein containing 160 mg of total isoflavones vs taste‐matched placebo (20 g whole milk protein). The study was conducted at a tertiary care center in the United States. Thirty‐three men (isoflavones = 17, placebo = 16) undergoing ADT for PCa completed this pilot study. Mean age in the 2 groups was 69 years and the majority of men were Caucasians. Mean duration of ADT in both groups was approximately 2 years (P = .70). The 2 groups were well matched at baseline. After 12 weeks of intervention, there was no significant difference in either metabolic or inflammatory parameters between the 2 groups. We found that high‐dose isoflavones over a course of 12 weeks do not improve metabolic or inflammatory parameters in androgen‐deprived men.