Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects

• Published in: British journal of nutrition Vol. 109; no. 10; pp. 1789 - 1795
• Main Authors: Spadafranca, Angela, Rinelli, Samuele, Riva, Antonella, Morazzoni, Paolo, Magni, Paolo, Bertoli, Simona, Battezzati, Alberto
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.05.2013
• Subjects: Adult; Appetite; Appetite Regulation - drug effects; Beans; Biological and medical sciences; blood glucose; Blood Glucose - metabolism; c-peptide; C-Reactive Protein - metabolism; Carbohydrates; Diabetes Mellitus - blood; Diabetes Mellitus - drug therapy; Diet; Dietary Supplements; Double-Blind Method; Feeding. Feeding behavior; Female; food intake; Fundamental and applied biological sciences. Psychology; ghrelin; Ghrelin - blood; glucose; Humans; Insulin; Insulin - blood; Lipids; Male; Metabolism; Metabolism and Metabolic Studies; Obesity - blood; Obesity - drug therapy; Phaseolus; Phaseolus vulgaris; Phytotherapy; placebos; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Postprandial Period; Reference Values; rodents; Satiation - drug effects; satiety; secretion; sensation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; Young Adult; Satiety; Glucose metabolism; Phaseolus vulgaris; Mixed meals; Supplements; Appetite; Human; Healthy subject; Nutrition; Meal; Extract; Glucose; Metabolism; Leguminosae; Mixed; Dicotyledones; Angiospermae; Carbohydrate; Spermatophyta
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114512003741

Extracts of Phaseolus vulgaris (beans) are known to reduce glycaemia and food intake in rodents and humans. The present study evaluated the effects of a new, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), on glycometabolic and appetite control. To this end, a randomised, double-blind, placebo-controlled study was performed in twelve volunteers. Plasma glucose, insulin, C-peptide, ghrelin and satiety sensation ratings were assessed at baseline and during 3 h after meal consumption associated with PVE (100 mg) or placebo. Compared with placebo, PVE consumption resulted in lower increments in glucose (+15·4 (sem 5·4) v. 26·1 (sem 7·3) %, P= 0·04 at 30 min), insulin (+981 (sem 115) v. 1325 (sem 240) %, P= 0·04 between 45 and 120 min) and C-peptide (+350 (sem 27) v. 439 (sem 30) %, P= 0·04 between 30 and 90 min). In the first 2 h, plasma ghrelin decreased similarly in both groups but did not rebound as in placebo thereafter (P= 0·04). Correspondingly, satiety sensation in the third hour was significantly reduced in the placebo but not in the PVE condition. PVE induced a lower desire to eat than placebo (P= 0·02) over the 3 h. In conclusion, PVE supplementation reduced postprandial glucose, insulin and C-peptide excursions, suppressed ghrelin secretion and affected satiety sensations, inducing a lower desire to eat. These results support that further studies are needed to prove the concept of employing PVE as a supplement in mixed balanced meals in obese, glucose-intolerant and diabetic subjects.