Predictors of Target Lesion Revascularization and Documented Stent Thrombosis Beyond 30 Days After Sirolimus-Eluting Stent Implantation Retrospective Analysis in Consecutive 1,070 Angiographic Follow-up Lesions

• Published in: Circulation Journal Vol. 71; no. 8; pp. 1328 - 1331
• Main Authors: Mutoh, Makoto, Ishikawa, Tetsuya, Hasuda, Toshio, Okada, Hisayuki, Endo, Akira, Miyanaga, Satoru, Higashitani, Michiaki, Nakano, Yosuke, Kubota, Takeyuki, Nakata, Koutarou, Nagoshi, Tomohisa, Hayashi, Mayuri, Sakamoto, Hiroshi, Oota, Masato, Imai, Kamon, Mochizuki, Seibu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2007
• Subjects: Coronary Angiography; Female; Graft Occlusion, Vascular; Humans; Male; Myocardial Revascularization; Percutaneous coronary intervention; Predictive Value of Tests; Prognosis; Restenosis; Retrospective Studies; Revascularization; Sirolimus - administration & dosage; Sirolimus-eluting stent; Stent thrombosis; Stents - adverse effects; Thrombosis - etiology
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.71.1328

Background Outcomes after sirolimus-eluting stent (SES: Cypher®) implantation remained to be elucidated in Japan. Methods and Results Among 1,070 consecutive angiographic follow-up lesions, 99 lesions underwent target lesion revascularization (TLR) with in-stent restenosis (ISR). Retrospective estimation by multivariate analysis including 50 variables showed that the ostiums of right coronary and left circumflex arteries, hemodialysis, calcification, non-direct stenting, ISR of SES, and non-eccentric lesion were the predictors of TLR. There was no documented late stent thrombosis (LST) among 2,166 lesions and very LST (VLST) among 1,423 lesions. Conclusion Further revises are needed to implant SES to these predictive lesions. LST and VLST were very rare. (Circ J 2007; 71: 1328 -1331)