C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism

• Published in: Journal of vascular surgery Vol. 49; no. 1; pp. 178 - 184
• Main Authors: Badger, Stephen A., MD, MRCS, Soong, Chee V., MD, FRCS, O' Donnell, Mark E., MB, MRCS, Mercer, Caroline, PhD, Young, Ian S., MD, FRCP, Hughes, Anne E., PhD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 2009; Elsevier
• Subjects: Aged; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - immunology; Aortic Aneurysm, Abdominal - pathology; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Cardiology. Vascular system; Case-Control Studies; Diseases of the aorta; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Up-Regulation; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Human; Cardiovascular disease; C reactive protein; Aortic aneurysm; Surgery; Polymorphism

Objective C-reactive protein (CRP) is a marker of cardiovascular disease. The objective was to determine if abdominal aortic aneurysm (AAA) and CRP serum concentration and its CRP gene are associated. Methods and Results AAA patients and AAA negative controls were recruited. CRP concentration was me...