C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism

• Published in: Journal of vascular surgery Vol. 49; no. 1; pp. 178 - 184
• Main Authors: Badger, Stephen A., MD, MRCS, Soong, Chee V., MD, FRCS, O' Donnell, Mark E., MB, MRCS, Mercer, Caroline, PhD, Young, Ian S., MD, FRCP, Hughes, Anne E., PhD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 2009; Elsevier
• Subjects: Aged; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - immunology; Aortic Aneurysm, Abdominal - pathology; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Cardiology. Vascular system; Case-Control Studies; Diseases of the aorta; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Up-Regulation; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Human; Cardiovascular disease; C reactive protein; Aortic aneurysm; Surgery; Polymorphism
• ISSN: 0741-5214; 1097-6809
• DOI: 10.1016/j.jvs.2008.07.081

Objective C-reactive protein (CRP) is a marker of cardiovascular disease. The objective was to determine if abdominal aortic aneurysm (AAA) and CRP serum concentration and its CRP gene are associated. Methods and Results AAA patients and AAA negative controls were recruited. CRP concentration was measured and the single nucleotide polymorphism (SNP), rs3091244, assessed. AAA cases were divided into those measuring 30-55 mm and >55 mm in diameter, to assess correlation of CRP with AAA size. A total of 248 (227 male) cases and 400 (388 male) controls were included. CRP concentration was higher in cases (385.0 μl/dL [310.4-442.8] vs 180.3 μl/dL [168.1-196.9]; P < .0001). It was higher in large aneurysms (685.7 μl/dL [511.8-1083.0] vs 291.0 μl/dL [223.6-349.6]; P < .0001), with significant correlation observed to size ( r = 0.37, P < .0001). CC was the most common SNP genotype with no difference in distribution ( P = .43) between cases and controls. No difference existed in CRP for each genotype in the overall cohort ( P = .17), cases ( P = .18) and controls ( P = .19). Conclusion The results demonstrate that CRP production may be related to the presence of AAA, especially in advanced disease. The serum concentration of CRP does not appear to be influenced by the functional SNP of the CRP gene, which also appears to have no association with AAA formation.