Testosterone therapy and cardiovascular risk

Abstract Endogenous testosterone levels are inversely associated with cardiovascular risk in older men and men with cardiovascular disease. Current data on cardiovascular outcomes of testosterone therapy include only observational studies and adverse event monitoring in short-term trials that were n...

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Bibliographic Details
Published inTrends in cardiovascular medicine Vol. 25; no. 3; pp. 250 - 257
Main Authors Walsh, James P., MD, PhD, Kitchens, Anne C., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2015
Elsevier Limited
Subjects
Adult
Androgens
Cardiovascular
Cardiovascular Diseases - chemically induced
Cardiovascular System - drug effects
Heart attacks
Hormone Replacement Therapy - adverse effects
Humans
Male
Men
Mortality
Older people
Risk Factors
Testosterone - adverse effects
Testosterone - therapeutic use
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Summary:Abstract Endogenous testosterone levels are inversely associated with cardiovascular risk in older men and men with cardiovascular disease. Current data on cardiovascular outcomes of testosterone therapy include only observational studies and adverse event monitoring in short-term trials that were not designed to measure cardiovascular outcomes. These studies have yielded conflicting results, and some have raised concerns that testosterone therapy may increase cardiovascular risk. A well-designed, adequately powered, prospective trial will ultimately be required to clarify whether testosterone therapy impacts cardiovascular outcomes. This review describes the findings and limitations of recent studies of cardiovascular risk in older men on testosterone therapy and discusses some of the mechanisms through which testosterone may modify cardiovascular risk.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2014.10.014