New cyclometalated transition-metal based photosensitizers for singlet oxygen generation and photodynamic therapy

• Published in: Science China. Chemistry Vol. 59; no. 1; pp. 40 - 52
• Main Authors: Jiang, Xinpeng, Zhu, Ningbo, Zhao, Dahui, Ma, Yuguo
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.01.2016; Springer Nature B.V
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Coordination compounds; Iridium; Oxygen production; Photodynamic therapy; Reviews; Singlet oxygen; Transition metal compounds; 光动力疗法; 光敏剂; 单线态氧; 单重态氧; 过渡金属配合物; 金属化; 金属基; 铂配合物; singlet oxygen; cyclometalated; photodynamic therapy; photosensitizer; transition-metal complexes
• ISSN: 1674-7291; 1869-1870
• DOI: 10.1007/s11426-015-5519-2

The aim of this review article is to introduce recent studies on an emergent class of singlet oxygen photosensitizers of potential applications to the photodynamic therapy,with a primary focus on the cyclometalated transition-metal complexes.Singlet oxygen photosensitization performances of various cyclometalated Ir and Pt scaffolds are reviewed,and the general photophysical properties of relevant systems and the mechanisms of singlet oxygen production via photo-sensitization are also briefly discussed.Thus far,investigations of singlet oxygen sensitization by such Ir and Pt complexes are mainly carried out in organic solvents and under non-physiological conditions,while some research efforts have been made at examining the feasibility of applying pertinent cyclometalated complexes to photodynamic therapy.