Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

• Published in: Biomolecules (Basel, Switzerland) Vol. 13; no. 4; p. 655
• Main Authors: You, He, Lu, Bai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.04.2023; MDPI
• Subjects: Bdnf promoters; Binding sites; Brain; Brain - metabolism; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cognitive ability; Electroconvulsive therapy; Exons; Humans; Hypothalamus; Investigations; Mental disorders; Neurons; non-coding exons; Non-coding RNA; Physiology; Promoter Regions, Genetic; Promoters; Proteins; Review; Schizophrenia; Schizophrenia - metabolism; Bdnf promoters; non-coding exons; brain-derived neurotrophic factor
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom13040655

The gene encoding brain-derived neurotrophic factor ( ) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine transcripts that play different roles in various brain regions and physiological stages. In this manuscript, we present a comprehensive overview of the molecular regulation and structural characteristics of the multiple promoters, along with a summary of the current knowledge on the cellular and physiological functions of the distinct transcripts produced by these promoters. Specifically, we summarized the role of transcripts in psychiatric disorders, including schizophrenia and anxiety, as well as the cognitive functions associated with specific promoters. Moreover, we examine the involvement of different promoters in various aspects of metabolism. Finally, we propose future research directions that will enhance our understanding of the complex functions of and its diverse promoters.