Pathogen free conditions slow the onset of neurodegeneration in a mouse model of nerve growth factor deprivation

Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbi...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 31; no. 1; p. 1
Main Authors Capsoni, Simona, Carucci, Nicola Maria, Cattaneo, Antonino
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2012
Subjects
Animals
Caliciviridae Infections - complications
Choline O-Acetyltransferase - metabolism
Cognition Disorders - etiology
Disease Models, Animal
Disease Progression
Humans
Interleukin-6 - blood
Lipopolysaccharides - toxicity
Mice
Mice, Transgenic
Nerve Growth Factor - deficiency
Neurodegenerative Diseases - blood
Neurodegenerative Diseases - complications
Neurodegenerative Diseases - etiology
Neurodegenerative Diseases - pathology
Norovirus - pathogenicity
tau Proteins - metabolism
Trichomonas Infections - complications
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Summary:Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbial environment and the onset of neurodegeneration in Alzheimer's disease animal models are lacking. Here we show that the onset of neurodegeneration that transgenic mice develop when raised in conventional husbandry slows down when raising anti-nerve growth factor transgenic mice in a murine pathogen free condition.
ISSN:1875-8908
DOI:10.3233/jad-2012-120427