Amsterdam Dementia Cohort: Performing Research to Optimize Care

The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated to combine both patient care and research. Together, to date, all patients forming the Amsterdam Dementia Cohort number almost 6,000 individuals. In this cohort profile, we provide an overview of the results pr...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 62; no. 3; pp. 1091 - 1111
Main Authors van der Flier, Wiesje M., Scheltens, Philip
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2018
Subjects
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - therapy
Biomarkers - cerebrospinal fluid
Brain - diagnostic imaging
Brain - physiopathology
Cohort Studies
Early Diagnosis
Humans
Magnetic Resonance Imaging
Netherlands
Quality Improvement
Surveys and Questionnaires
Netherlands
vascular factors
Alzheimer’s disease
Amsterdam Dementia Cohort
dementia
diagnosis
mild cognitive impairment
prognosis
heterogeneity
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Summary:The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated to combine both patient care and research. Together, to date, all patients forming the Amsterdam Dementia Cohort number almost 6,000 individuals. In this cohort profile, we provide an overview of the results produced based on the Amsterdam Dementia Cohort. We describe the main results over the years in each of these research lines: 1) early diagnosis, 2) heterogeneity, and 3) vascular factors. Among the most important research efforts that have also impacted patients’ lives and/or the research field, we count the development of novel, easy to use diagnostic measures such as visual rating scales for MRI and the Amsterdam IADL Questionnaire, insight in different subgroups of AD, and findings on incidence and clinical sequelae of microbleeds. Finally, we describe in the outlook how our research endeavors have improved the lives of our patients.
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-170850