A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters

The rates of reaction with ozone of some biological antioxidants and simple polyunsaturated fatty acids (PUFA) have been measured in water or in aqueous micellar solutions. At pH 7.0 the rate constants are ca . 10 6 M −1sec −1 for urate, alpha-tocopherol, and PUFA, and 6 × 10 7 M −1sec −1 for ascorb...

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Published inBiochemical and biophysical research communications Vol. 133; no. 2; pp. 773 - 779
Main Authors Giamalva, David, Church, Daniel F., Pryor, William A.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 17.12.1985
Elsevier
Subjects
Antioxidants
Applied sciences
Ascorbic Acid
Chemical Phenomena
Chemistry
Exact sciences and technology
Fatty Acids, Unsaturated
Linoleic Acid
Linoleic Acids
Oleic Acid
Oleic Acids
Other techniques and industries
Ozone
Uric Acid
Vitamin E
PUFA
a-T
SDS
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Summary:The rates of reaction with ozone of some biological antioxidants and simple polyunsaturated fatty acids (PUFA) have been measured in water or in aqueous micellar solutions. At pH 7.0 the rate constants are ca . 10 6 M −1sec −1 for urate, alpha-tocopherol, and PUFA, and 6 × 10 7 M −1sec −1 for ascorbate. When ozone-containing air is breathed, ascorbate in the lung may undergo direct ozonation. However, alpha-tocopherol is probably spared direct reaction with ozone because it doesn't effectively compete with PUFA in pulmonary membranes; rather, tocopherol is used to scavenge radicals produced from the ozone-PUFA reaction.
Bibliography:ObjectType-Article-1
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(85)90971-4