Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat

Erythema induratum of Bazin (EIB) is a predominantly lobular panniculitis with or without vasculitis due to Mycobacterium tuberculosis (MTB) infection. Atrophic scars may remain after EIB was healed. Rare cases of EIB showing sharp skin depression may mimic deep morphea and lupus profundus. A rare c...

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Published inInternational medical case reports journal Vol. 14; pp. 777 - 781
Main Authors Dharmadji, Hartati Purbo, Suwarsa, Oki, Sutedja, Endang, Pangastuti, Miranti, Gunawan, Hendra, Makarti, Kristina
Format Journal Article
LanguageEnglish
Published Macclesfield Dove Medical Press Limited 30.11.2021
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects
Atrophy
Biopsy
Case Report
Case reports
Deoxyribonucleic acid
Disease
DNA
Erythema
erythema induratum of bazin
Ethambutol
Health aspects
Histopathology
Infection
Infections
Inflammation
Legs
Lupus
mycobacterium tuberculosis
Overweight
panniculitis
Patients
Polymerase chain reaction
Scintigraphy
Skin
Tuberculosis
Ulcers
Varicose veins
Indonesia
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Summary:Erythema induratum of Bazin (EIB) is a predominantly lobular panniculitis with or without vasculitis due to Mycobacterium tuberculosis (MTB) infection. Atrophic scars may remain after EIB was healed. Rare cases of EIB showing sharp skin depression may mimic deep morphea and lupus profundus. A rare case of EIB was reported in a 35-year-old female with slightly tender erythematous-violaceous nodules and hyperpigmented depressed scars on both lower legs, resulting in asymmetrical lower leg shape. Histopathological examination showed lobular panniculitis without vasculitis and granulomatous inflammation consisted of caseous necrosis, epithelioid cells, and multinucleated giant cells. Polymerase chain reaction (PCR) from skin biopsy revealed deoxyribonucleic acid (DNA) of MTB. Tuberculin skin test (TST) was positive with a 20-mm induration, and nuclear 99mTc-ethambutol scintigraphy was positive for tuberculosis infection in one-third distal portion of the left lower leg. Clinical improvements were shown after 6 months of antituberculosis therapy. EIB must be considered in patient with erythematous-violaceous nodules on lower leg, especially in endemic areas of tuberculosis infection since diagnosis can be difficult and occasionally, deceptive. Keywords: erythema induratum of Bazin, Mycobacterium tuberculosis, panniculitis
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S336088