Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

• Published in: Acta oncologica Vol. 58; no. 7; pp. 977 - 982
• Main Authors: Nahavandipour, Arvin, Jakobsen, Kathrine Kronberg, Grønhøj, Christian, Hebbelstrup Jensen, David, Kim Schmidt Karnov, Kirstine, Klitmøller Agander, Tina, Specht, Lena, von Buchwald, Christian
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.07.2019
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - pathology; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Denmark - epidemiology; Female; Humans; Incidence; Laryngeal Neoplasms - epidemiology; Laryngeal Neoplasms - pathology; Male; Middle Aged; Neuroendocrine Tumors - epidemiology; Neuroendocrine Tumors - pathology; Registries - statistics & numerical data; Sex Factors; Squamous Cell Carcinoma of Head and Neck - epidemiology; Squamous Cell Carcinoma of Head and Neck - pathology; Survival Analysis; Survival Rate - trends; Young Adult; Denmark
• ISSN: 0284-186X; 1651-226X
• DOI: 10.1080/0284186X.2019.1572923

Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014. Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980-2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. We evaluated the relative survival at five years in relation to gender, anatomical location, year at diagnosis, and histological type. Further, an age-period-cohort (APC) model of incidence was constructed. Results: A total of 8748 patients (82% males) were included. The median age at diagnosis was 60 years, range 18-101 years. The AAIR decreased from 3.6 per 100,000 in 1980 to 2.3 per 100,000 in 2014 with an AAPC of -0.8% (p < .008). Considering the anatomic location, we found that glottic cancer had a significantly better survival at five years compared to the other locations. We observed no significant difference in survival for supraglottic, subglottic and larynx unspecified cancer during the observation period. During the period 1980-2014, we found no improvement in five year relative survival. Conclusions: This nation-wide study reports a significant decrease in the incidence of laryngeal cancer. Glottic cancer had a significantly better survival at five years compared to other locations.