Your neighbours matter – non-autonomous control of apoptosis in development and disease

Traditionally, the regulation of apoptosis has been thought of as an autonomous process in which the dying cell dictates its own demise. However, emerging studies in genetically tractable multicellular organisms, such as Caenorhabditis elegans and Drosophila , have revealed that death is often a com...

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Bibliographic Details
Published inCell death and differentiation Vol. 23; no. 7; pp. 1110 - 1118
Main Authors Eroglu, M, Derry, W B
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2016
Nature Publishing Group
Subjects
631/208/135
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans Proteins - metabolism
Caspases - metabolism
Cell Biology
Cell Cycle Analysis
Cell death
Disease
Drosophila
Drosophila Proteins - metabolism
Growth factors
Humans
Insects
Kinases
Life Sciences
MAP Kinase Signaling System
Membrane Proteins - metabolism
Organisms
Proteins
Review
Sarcoma
Stem Cells
Tumor necrosis factor-TNF
Canada
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Summary:Traditionally, the regulation of apoptosis has been thought of as an autonomous process in which the dying cell dictates its own demise. However, emerging studies in genetically tractable multicellular organisms, such as Caenorhabditis elegans and Drosophila , have revealed that death is often a communal event. Here, we review the current literature on non-autonomous mechanisms governing apoptosis in multiple cellular contexts. The importance of the cellular community in dictating the funeral arrangements of apoptotic cells has profound implications in development and disease.
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ISSN:1350-9047
1476-5403
DOI:10.1038/cdd.2016.41