Celiac artery thrombosis in a young patient with multiple platelet receptor polymorphisms and local compression syndrome

• Published in: Journal of vascular surgery Vol. 48; no. 5; pp. 1335 - 1337
• Main Authors: Rudolph, Jens, MD, Pourhassan, Siamak, MD, Saner, Fuat, MD, Zotz, Rainer B., MD, Sandmann, Wilhelm, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.11.2008; Elsevier
• Subjects: Acute Disease; Adult; Anticoagulants - therapeutic use; Arterial Occlusive Diseases - diagnostic imaging; Arterial Occlusive Diseases - etiology; Arterial Occlusive Diseases - genetics; Arterial Occlusive Diseases - therapy; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Celiac Artery - diagnostic imaging; Celiac Artery - surgery; Decompression, Surgical; Female; Humans; Integrin alpha2beta1 - genetics; Medical sciences; Pharmacology. Drug treatments; Platelet Glycoprotein GPIIb-IIIa Complex - genetics; Polymorphism, Genetic; Risk Factors; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Syndrome; Thrombectomy; Thrombosis - diagnostic imaging; Thrombosis - etiology; Thrombosis - genetics; Thrombosis - therapy; Tomography, X-Ray Computed; Treatment Outcome; Vascular Diseases - complications; Vascular Diseases - diagnostic imaging; Vascular Diseases - surgery; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Arterial disease; Vascular disease; Human; Platelet; Surgery; Cardiovascular disease; Artery thrombosis; Polymorphism
• ISSN: 0741-5214; 1097-6809
• DOI: 10.1016/j.jvs.2008.05.038

Numerous clinical and experimental studies have been published concerning platelet receptor polymorphism and their role in causing myocardial infarction at an earlier age. It is still unclear, however, whether these polymorphisms are a risk factor for other occlusive diseases such as those in visceral arteries. We report a case of a young woman with acute celiac artery thrombosis and multiple platelet receptor polymorphisms. In addition, the intraoperative exploration showed some evidence of a local vascular compression syndrome. The patient was successfully treated with a bypass procedure and combined anticoagulation. It seems that platelet receptor polymorphisms are a moderate risk factor for local artery thrombosis regardless of vascular region. The obligatory precondition is pre-existing vascular damage, such as that caused by a local compression syndrome.