Microfluidic spinning of micro- and nano-scale fibers for tissue engineering
Microfluidic technologies have recently been shown to hold significant potential as novel tools for producing micro- and nano-scale structures for a variety of applications in tissue engineering and cell biology. Over the last decade, microfluidic spinning has emerged as an advanced method for fabri...
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| Published in | Lab on a chip Vol. 14; no. 13; pp. 2145 - 216 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2014
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Microfluidic technologies have recently been shown to hold significant potential as novel tools for producing micro- and nano-scale structures for a variety of applications in tissue engineering and cell biology. Over the last decade, microfluidic spinning has emerged as an advanced method for fabricating fibers with diverse shapes and sizes without the use of complicated devices or facilities. In this critical review, we describe the current development of microfluidic-based spinning techniques for producing micro- and nano-scale fibers based on different solidification methods, platforms, geometries, or biomaterials. We also highlight the emerging applications of fibers as bottom-up scaffolds such as cell encapsulation or guidance for use in tissue engineering research and clinical practice.
Microfluidic-based spinning techniques for producing micro- and nano-scale fibers, and their potential applications to tissue engineering are reviewed. |
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| Bibliography: | Sang-Hoon Lee is professor in the department of Biomedical Engineering at Korea University. He received a B.S. degree in electrical engineering and M.S. and Ph.D. degrees in biomedical engineering from the Seoul National University in Korea, in 1983, 1987 and 1992, respectively. From 1992 to 2006, he was Professor in the Department of Biomedical Engineering at the Dankook University. His current interests are the development of microfluidic devices to provide microenvironments for cell study and tissue engineering, microfluidic spinning for bioartificial organs, cell encapsulation with hydrogels, and flexible, stretchable and implantable sensors for biomedical applications. Yesl Jun is a Ph.D. student at Korea University in Biotechnology-Medical Science from the KU-KIST Graduate School of Converging Science and Technology. She received her B.S. (2012) and M.S. (2014) degrees in Biomedical Engineering from Korea University. Her research interests include bioartificial organs, microfluidics, organ-on-a-chip, and tissue engineering. Dr. Sukyoung Chae is a Post-Doctoral Fellow at Harvard-MIT Health Science and Technology, with a Ph.D. in chemical engineering from Korea Institute of Science and Technology and Academic Program at Yonsei University, South Korea, a Masters in Physical Chemistry from Jeonbuk National University, South Korea, and a B.Sc. in Chemistry from Jeonbuk National University, South Korea. She has been working on surface science and micro/nano technologies of microfluidic systems. Her research interests include microfluidic systems, surface chemistry, bio/environment sensors, tissue engineering, biomaterials, and food engineering. Edward Kang is a Ph.D. student in Biomedical Engineering at the Korea University, and M.D. candidate at the Korea University School of Medicine. His research interests include lab-on-a-chip devices for clinical diagnostics and regenerative medicine. He received his B.S. in aerospace engineering from Korea Aerospace University in 2008 and M.S. from Korea University in 2010 with Sang-Hoon Lee. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1473-0197 1473-0189 |
| DOI: | 10.1039/c3lc51414e |