Plasmidic versus Insertional Cloning of Heterologous Genes in Mycobacterium bovis BCG: Impact on In Vivo Antigen Persistence and Immune Responses

• Published in: Infection and Immunity Vol. 70; no. 1; pp. 303 - 314
• Main Authors: MEDERLE, I, BOURGUIN, I, ENSERGUEIX, D, BADELL, E, MONIZ-PEIREIRA, J, GICQUEL, B, WINTER, N
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.01.2002
• Subjects: Animals; Antibodies, Viral - immunology; Antigens, Viral - genetics; Antigens, Viral - immunology; Bacteriology; Bacteriophages; Biological and medical sciences; Cells, Cultured; Chromosomes, Bacterial; Cloning, Molecular - methods; DNA, Viral; Female; Fundamental and applied biological sciences. Psychology; gag gene; Gene Expression; Gene Products, gag - genetics; Gene Products, gag - immunology; Gene Products, nef - genetics; Gene Products, nef - immunology; Genetic Vectors - genetics; Genetics; Life Sciences; Macrophages - cytology; Macrophages - immunology; Mice; Mice, Inbred BALB C; Microbial Immunity and Vaccines; Microbiology; Microbiology and Parasitology; Mutagenesis, Insertional - methods; Mutagenesis, Site-Directed; Mycobacterium bovis; Mycobacterium bovis - genetics; Mycobacterium bovis - virology; nef gene; Operon; Plasmids; Simian immunodeficiency virus; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; T-Lymphocytes - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Mycobacterial infection; Site specificity; Specificity; Gene; Bacteria; Vector; Immunopathology; Immune response; Mycobacterium bovis; Operon; Retroviridae; Chromosome; Gene expression; Lentivirus; Immune deficiency; Infection; Virus; Antigen; Plasmid; Tuberculosis; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Replication; Actinomycetes; Simian immunodeficiency virus; PROTECTIVE IMMUNITY; RHESUS-MONKEYS; BACILLE CALMETTE-GUERIN; TUBERCULOSIS; OSPA LIPOPROTEIN; MICE; INFECTION; LYME-DISEASE VACCINE; SURFACE PROTEIN-A; NEF
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.70.1.303-314.2002

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