Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function
The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structur...
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| Published in | International journal of molecular sciences Vol. 24; no. 4; p. 3386 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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08.02.2023
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| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms24043386 |
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| Abstract | The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed. |
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| AbstractList | The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed. The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed.The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed. |
| Audience | Academic |
| Author | Qiu, Lijuan Ren, An-Jing Zhong, Shan Chao, Wen |
| AuthorAffiliation | Experimental Teaching Center, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China |
| AuthorAffiliation_xml | – name: Experimental Teaching Center, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China |
| Author_xml | – sequence: 1 givenname: Lijuan surname: Qiu fullname: Qiu, Lijuan – sequence: 2 givenname: Wen surname: Chao fullname: Chao, Wen – sequence: 3 givenname: Shan surname: Zhong fullname: Zhong, Shan – sequence: 4 givenname: An-Jing surname: Ren fullname: Ren, An-Jing |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36834797$$D View this record in MEDLINE/PubMed |
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| Keywords | translation cancer ribosomal protein S5 liver disease function |
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| SubjectTerms | Amino acids Apoptosis Cell division Eukaryota - genetics Genetic translation Humans Insects Liver diseases Mutation Prokaryotes Protein synthesis Proteins Review Ribosomal Proteins - metabolism Ribosomes - metabolism RNA RNA, Ribosomal, 18S - metabolism Transfer RNA Yeast |
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| Title | Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function |
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