Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function

The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structur...

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Published inInternational journal of molecular sciences Vol. 24; no. 4; p. 3386
Main Authors Qiu, Lijuan, Chao, Wen, Zhong, Shan, Ren, An-Jing
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.02.2023
MDPI
Subjects
Amino acids
Apoptosis
Cell division
Eukaryota - genetics
Genetic translation
Humans
Insects
Liver diseases
Mutation
Prokaryotes
Protein synthesis
Proteins
Review
Ribosomal Proteins - metabolism
Ribosomes - metabolism
RNA
RNA, Ribosomal, 18S - metabolism
Transfer RNA
Yeast
translation
cancer
ribosomal protein S5
liver disease
function
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Summary:The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043386