Update on the diagnosis and management of autoimmune encephalitis

In recent years, autoimmunity has been increasingly recognised as an important cause of encephalitis. Many different antibodies are now known to target antigens on the neuronal surface, and some of these are associated with characteristic clinical presentations, although seronegative cases are also...

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Bibliographic Details
Published inClinical medicine (London, England) Vol. 20; no. 4; pp. 389 - 392
Main Authors Ellul, Mark A, Wood, Greta, Tooren, Harriet Van Den, Easton, Ava, Babu, Ashik, Michael, Benedict D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.2020
Royal College of Physicians
Subjects
Antibodies
Antigens
Autoantibodies
Autoimmune diseases
autoimmunity
CME: Neurology
Convulsions & seizures
Disease
Dyskinesia
Electroencephalography
Encephalitis
Encephalitis - diagnosis
Encephalitis - therapy
Hashimoto Disease - diagnosis
Hashimoto Disease - therapy
Humans
limbic encephalitis
Magnetic resonance imaging
Medical imaging
Mental Disorders
Movement disorders
Nervous system
Neuroimmunology
NMDA-R encephalitis
Ovaries
Proteins
limbic encephalitis
autoimmunity
NMDA-R encephalitis
Neuroimmunology
encephalitis
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Summary:In recent years, autoimmunity has been increasingly recognised as an important cause of encephalitis. Many different antibodies are now known to target antigens on the neuronal surface, and some of these are associated with characteristic clinical presentations, although seronegative cases are also recognised. Autoimmune encephalitis may mimic other conditions, including primary psychiatric disorders, particularly early in the disease. Because early immune treatment of autoimmune encephalitis improves patient outcomes, and indeed many make a good recovery, it is important to recognise these syndromes promptly.
ISSN:1470-2118
1473-4893
DOI:10.7861/clinmed.2020-0241