Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma

•Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets.•Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.

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Bibliographic Details
Published inBlood advances Vol. 4; no. 19; pp. 4769 - 4774
Main Authors Huang, Dachuan, Lim, Jing Quan, Cheah, Daryl Ming Zhe, Kahliab, Khalilatul Hanisah Binte Mohd, Laurensia, Yurike, Pang, Jane Wan Lu, Wong, Esther Kam Yin, Chia, Burton Kuan Hui, Goh, Jasmine, Zhang, Xiyun, Chan, Jason Yongsheng, Chow, Edward Kai-Hua, Tan, Soo Yong, Lim, Soon Thye, Ong, Choon Kiat
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.10.2020
American Society of Hematology
Subjects
Humans
Lymphoma, T-Cell
Stimulus Report
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Summary:•Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets.•Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.
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D.H. and J.Q.L. contributed equally to this study.
E.K.-H.C., S.Y.T., S.T.L., and C.K.O. contributed equally to this study.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2020001782