Multivariate analysis reveals oral health-related quality of life of complete denture wearers with denture adhesives: a multicenter randomized controlled trial

• Published in: Journal of Prosthodontic Research Vol. 65; no. 3; pp. 353 - 359
• Main Authors: Murakami, Mamoru, Hamada, Taizo, Ohwada, Gaku, Ito, Yoshihiko, Nomura, Taro, Sato, Yohei, Okazaki, Joji, Kondo, Hisatomo, Suzuki, Asako, Suzuki, Tetsuya, Tsuboi, Akito, Morokuma, Masakazu, Maeda, Takeshi, Kawai, Yasuhiko, Nakai, Kenichiro, Nagao, Kan, Kimoto, Suguru, Minakuchi, Shunsuke, Saita, Makiko, Takase, Kazuma, Kimoto, Katsuhiko, Hoshi, Noriyuki, Yoneyama, Yoshikazu, Murata, Hiroshi, Ichikawa, Tetsuo, Nishimura, Masahiro, Fujimoto, Keiko, Nishi, Yasuhiro, Hong, Guang, Gunji, Atsuko, Kurogi, Tadafumi, Hosoi, Toshio, Sato, Yusuke
• Format: Journal Article
• Language: English
• Published: Japan Prosthodontic Society 01.01.2021
• Subjects: Complete denture; Denture adhesive; Multivariate analysis; OHR-QoL
• ISSN: 1883-1958; 2212-4632; 1883-9207; 2212-4632
• DOI: 10.2186/jpr.JPR_D_20_00132

Purpose To investigate the difference in improvement of oral health-related quality of life (OHR-QoL) depending on the oral and denture conditions of a complete denture wearer when using a cream or powder type denture adhesive in a 10-center parallel randomized clinical trial.Methods Two hundred edentulous subjects who wore complete dentures were allocated to each of the three groups according to denture adhesive type: cream, powder, and control (saline solution). The materials were applied to the mucosal surface of the dentures for 4 days, and baseline data and data after the intervention were collected. OHR-QoL was assessed using the Japanese version of the modified Oral Health Impact Profile for Edentulous Patients (OHIP-EDENT-J) scale for outcome. Multivariate analysis was used to investigate improvements in OHR-QoL according to participant characteristics among complete denture wearers using these materials.Results OHIP-EDENT-J scores were significantly decreased in all groups after the intervention (p < 0.05); however, there were no statistically significant differences among the groups. Multiple logistic regression analysis revealed a significant association between the vertical height of the maxillary and mandibular alveolar ridge and OHIP-EDENT-J scores in the cream-type denture adhesive group. In contrast, there were no significant association between participant characteristics and OHIP-EDENT-J scores in the powder-type adhesive and control groups.Conclusions The use of denture adhesives could improve OHR-QoL for complete denture wearers. The cream-type denture adhesives may be expected to improve OHR-QoL in patients with poor residual ridge conditions compared with patients with good residual ridge conditions.