Ouabain increases neuronal differentiation of hippocampal neural precursor cells

[Display omitted] •Ouabain at a concentration of 10 nM does not affect the proliferation of hippocampal neural precursor cells.•OUA promotes the differentiation of NPCs into neurons.•OUA promotes increased dendritic branching in newly formed neurons.•In proliferative condition, OUA increases the lev...

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Published inCurrent research in neurobiology Vol. 8; p. 100147
Main Authors Orellana, Ana Maria, Port's, Natacha Medeiros S., de Sá Lima, Larissa, Leite, Jacqueline Alves, Andreotti, Diana Zukas, Kinoshita, Paula Fernanda, Cantanzaro, Arthur B., Neto, João Agostinho M., Scavone, Cristoforo, Kawamoto, Elisa M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2025
Elsevier
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Summary:[Display omitted] •Ouabain at a concentration of 10 nM does not affect the proliferation of hippocampal neural precursor cells.•OUA promotes the differentiation of NPCs into neurons.•OUA promotes increased dendritic branching in newly formed neurons.•In proliferative condition, OUA increases the levels of NeuroD2 mRNA while decreasing neurotrophin NT-3 levels.•During differentiation, OUA lowers the levels of NT-3 while increasing the levels of BDNF and NGF.
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ISSN:2665-945X
2665-945X
DOI:10.1016/j.crneur.2025.100147