Ultrastructural studies of spleen after whole body irradiation of mice

The ultrastructural changes in mouse spleen during the first 6 days after 800 roentgens of whole body irradiation have been described. Mature lymphocytes showed early cytonecrosis, characterized by marked cellular shrinkage without fragmentation and usually were phagocytized whole by reticular macro...

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Bibliographic Details
Published inExperimental and molecular pathology Vol. 6; no. 2; pp. 156 - 171
Main Author Jordan, S.W.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.01.1967
Subjects
Animals
Endoplasmic Reticulum
Fibroblasts - cytology
Golgi Apparatus
Histocytochemistry
Lymphocytes - cytology
Lymphoid Tissue - radiation effects
Macrophages - cytology
Male
Megakaryocytes - cytology
Mice
Microscopy, Electron
Necrosis
Phagocytosis
Plasma Cells - cytology
Radiation Effects
Reticulocytes - cytology
Spleen - cytology
Spleen - radiation effects
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Summary:The ultrastructural changes in mouse spleen during the first 6 days after 800 roentgens of whole body irradiation have been described. Mature lymphocytes showed early cytonecrosis, characterized by marked cellular shrinkage without fragmentation and usually were phagocytized whole by reticular macrophages, subsequently fragmented and were digested. Immature lymphocytes showed chromatin clumping, in addition to cyto-necrotic changes like those in mature lymphocytes but appeared less sensitive to radiation than mature lymphocytes. There was mild dilatation of ER cisterns in plasma cells, but reticular macrophages, megakaryocytes and fibroblasts appeared to be directly affected relatively little by radiation.
ISSN:0014-4800
1096-0945
DOI:10.1016/0014-4800(67)90053-6