The JAM family of junctional adhesion molecules

Junctional adhesion molecules are a family of glycoproteins characterised by two immunoglobulin folds (V H- and C 2-type) in the extracellular domain. Junctional adhesion molecule proteins localise to intercellular junctions of polarised endothelial and epithelial cells but can also be expressed on...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 15; no. 5; pp. 525 - 530
Main Author Bazzoni, Gianfranco
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2003
Subjects
Animals
Blood Platelets - metabolism
Cell Adhesion Molecules - metabolism
Cell Movement - physiology
Endothelium, Vascular - metabolism
Epithelial Cells - metabolism
Humans
Immunoglobulins - metabolism
Junctional Adhesion Molecules
Leukocytes - metabolism
Membrane Proteins - metabolism
Mice
Protein Structure, Tertiary
Tight Junctions - metabolism
HEV
ESAM
ZO-1
CAR
TJ
JAM
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Summary:Junctional adhesion molecules are a family of glycoproteins characterised by two immunoglobulin folds (V H- and C 2-type) in the extracellular domain. Junctional adhesion molecule proteins localise to intercellular junctions of polarised endothelial and epithelial cells but can also be expressed on circulating leukocytes and platelets. In addition, they bind several ligands, in both a homophilic and heterophilic manner, and associate with several cytoplasmic partners. All these features represent the likely determinants for the role of junctional adhesion molecule proteins in processes as diverse as junction assembly, leukocyte transmigration and platelet activation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(03)00104-2