No unfavorable effects on the menstruation recovery of early postoperative hypoprolactinemia after transsphenoidal surgery in patients with lactotroph pituitary neuroendocrine tumor

• Published in: BMC research notes Vol. 17; no. 1; pp. 212 - 6
• Main Authors: Ishida, Tomohisa, Kawaguchi, Tomohiro, Ogawa, Yoshikazu, Tominaga, Teiji, Endo, Hidenori
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.07.2024; BioMed Central; BMC
• Subjects: Adult; Brain; Clinical significance; Dopamine; Endocrine disorders; Endocrinological remission; Endoscopic transsphenoidal surgery; Endoscopy; Female; Females; Health aspects; Hormones; Humans; Hyperprolactinemia; Hyperprolactinemia - blood; Hyperprolactinemia - etiology; Hyperprolactinemia - physiopathology; Hyperprolactinemia - surgery; Hypoprolactinemia; Infertility; Lactotrophs; Menstruation; Menstruation - physiology; Middle Aged; Neuroendocrine system; Neuroendocrine tumors; Neuroendocrine Tumors - blood; Neuroendocrine Tumors - surgery; Ovaries; Patients; Physiological aspects; Pituitary; Pituitary gland; Pituitary Neoplasms - surgery; Postoperative Complications - etiology; Prolactin; Prolactin - blood; Regular menstruation restoration; Remission; Research Note; Retrospective Studies; Surgery; Women; Young Adult; Japan; Endocrinological remission; Hypoprolactinemia; Prolactin; Regular menstruation restoration; Endoscopic transsphenoidal surgery; Hyperprolactinemia
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-024-06866-w

Transsphenoidal surgery for lactotroph pituitary neuroendocrine tumor (PitNET) lowers serum prolactin concentrations, occasionally below the normal range. However, the clinical significance of postoperative hypoprolactinemia is still unclear. In this study, we retrospectively reviewed the female patients with lactotroph PitNET who were treated with transsphenoidal surgery to elucidate the influence of postoperative hypoprolactinemia on regular menstruation restoration and endocrinological remission. The serum prolactin levels in all thirty three participating females had decreased following surgery. Serum prolactin levels in seven patients had decreased below the lower limit of normal ranges (hypoproactinemia group) and in the remaining twenty six patients, it was within the normal range (non-hypoproractinemia group). In hypoprolactinemia group, regular menstruation was restored in all patients with only lactotroph axis deficiency. Nine patients from the non-hypoprolactinemia group experienced re-elevation of serum prolactin concentration (27%). No patient in hypoprolactinemia group experienced the relapse of hyperprolactinemia. These data suggest that early postoperative hypoprolactinemia after transsphenoidal surgery for lactotroph PitNET is not only a good predictive factor for endocrinological remission but also no unfavorable effects on regular menstruation restoration.