Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests

• Published in: Aquatic toxicology Vol. 90; no. 2; pp. 128 - 137
• Main Authors: Schirmer, Kristin, Tanneberger, Katrin, Kramer, Nynke I., Völker, Doris, Scholz, Stefan, Hafner, Christoph, Lee, Lucy E.J., Bols, Niels C., Hermens, Joop L.M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 11.11.2008; Amsterdam; New York: Elsevier Science; Elsevier
• Subjects: Acute fish lethality test; Agnatha. Pisces; Alternatives to animal testing; Animal Testing Alternatives; animal use alternatives; Animal, plant and microbial ecology; Animals; Applied ecology; Biological and medical sciences; Cell Line; Cell lines; Chemical database; Danio rerio; Databases, Factual; ecotoxicology; Ecotoxicology - methods; Ecotoxicology, biological effects of pollution; fish; Fish embryo; Freshwater; Fundamental and applied biological sciences. Psychology; General aspects; Inhibitory Concentration 50; lethal concentration 50; Lethal Dose 50; minnows; Organic Chemicals; organic compounds; Pimephales promelas; reference standards; Reference Values; toxicity testing; United States; United States Environmental Protection Agency; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution; United States; USA; IC 50; Acute fish lethality test; SDS; log HLC; DIN; LC 50; Chemical database; NPN; Alternatives to animal testing; REACh; log P; OECD; FET; QSAR; UBA; MEIC; U.S. EPA; Cell lines; Fish embryo; MOA; PN; Embryo; Ecotoxicology; Toxicity; Acute; Toxicity test; Aquatic environment; Vertebrata; Cell line; Pisces; Database; List

This paper details the derivation of a list of 60 reference chemicals for the development of alternatives to animal testing in ecotoxicology with a particular focus on fish. The chemicals were selected as a prerequisite to gather mechanistic information on the performance of alternative testing syst...