Field trial of two dual vaccines against Mycoplasma agalactiae and Mycoplasma mycoides subsp. mycoides (large colony type) in goats

• Published in: Vaccine Vol. 25; no. 12; pp. 2340 - 2345
• Main Authors: de la Fe, Christian, Assunção, Patricia, Saavedra, Pedro, Tola, Sebastiana, Poveda, Carlos, Poveda, José B
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 08.03.2007; Elsevier
• Subjects: Adjuvants, Immunologic - administration & dosage; Allergy and Immunology; Animals; Antibodies, Bacterial - blood; Applied microbiology; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; Bacteriology; Biological and medical sciences; Caprine contagious agalactia; Combined vaccine; DNA, Bacterial - analysis; Female; Field trial; Fundamental and applied biological sciences. Psychology; Goats; Microbiology; Milk - microbiology; Miscellaneous; Mycoplasma agalactiae; Mycoplasma agalactiae - genetics; Mycoplasma agalactiae - growth & development; Mycoplasma agalactiae - immunology; Mycoplasma Infections - blood; Mycoplasma Infections - immunology; Mycoplasma Infections - prevention & control; Mycoplasma mycoides; Mycoplasma mycoides - genetics; Mycoplasma mycoides - growth & development; Mycoplasma mycoides - immunology; Polymerase Chain Reaction; Pregnancy; Vaccination - methods; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Combined vaccine; Caprine contagious agalactia; Field trial; Mycoplasma agalactiae; Farming animal; Mixed vaccine; Mycoplasmataceae; Infection; Mollicutes; Mycoplasmatales; Mycoplasma mycoides; Vertebrata; Contagious agalactia; Mammalia; Bacteriosis; Bacteria; Goat; Artiodactyla; Mycoplasmal infection; Ungulata
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2006.11.050

Abstract Two vaccines against Mycoplasma agalactiae and Mycoplasma mycoides subsp. mycoides (LC type) were developed using inactivated strains selected in previous characterization studies. The vaccines differed in terms of the adjuvants used: aluminium hydroxide (vaccine A) or aluminium hydroxide plus purified saponin (vaccine B). These vaccines were tested on 60 pregnant goats and 60 seronegative kids that were challenged by placing in a herd with a history of caprine contagious agalactia (CCA). Our findings indicate the effectiveness of the vaccines in preventing the appearance of new clinical signs such as mastitis, abortion, pneumonia and polyarthritis in CCA affected herds.