Biologicals, platelet apoptosis and human diseases: An outlook

Highlights • Platelets play a major role in health and disease including heart diseases and cancer. • Commonly used biologicals induce increased platelet apoptosis and thrombocytopenia. • Increased platelet apoptosis causes excess microparticle formation which is dangerous. • Side-effects of biologi...

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Bibliographic Details
Published inCritical reviews in oncology/hematology Vol. 93; no. 3; pp. 149 - 158
Main Authors Thushara, R.M, Hemshekhar, M, Basappa, Kemparaju, K, Rangappa, K.S, Girish, K.S
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.03.2015
Subjects
Apoptosis - drug effects
Biologicals
Blood Platelet Disorders - etiology
Blood Platelets - drug effects
Blood Platelets - physiology
Cancer
Cardiovascular diseases
Cell-Derived Microparticles
Hematology, Oncology and Palliative Medicine
Humans
Microparticles
Platelet apoptosis
Cardiovascular diseases
Platelet apoptosis
Microparticles
Biologicals
Cancer
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Summary:Highlights • Platelets play a major role in health and disease including heart diseases and cancer. • Commonly used biologicals induce increased platelet apoptosis and thrombocytopenia. • Increased platelet apoptosis causes excess microparticle formation which is dangerous. • Side-effects of biologicals on platelets and the consequences are often neglected. • There is a need to overcome side-effects of proapoptotic drugs via auxiliary therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2014.11.002