A Cluster of Bunyavirus-Associated Severe Fever With Thrombocytopenia Syndrome Cases in a Coastal Plain Area in China, 2015: Identification of a Previously Unidentified Endemic Region for Severe Fever With Thrombocytopenia Bunyavirus

• Published in: Open forum infectious diseases Vol. 6; no. 6; p. ofz209
• Main Authors: Hu, Jianli, Li, Zhifeng, Cai, Jiaping, Liu, Donglin, Zhang, Xuefeng, Jiang, Renjie, Guo, Xilin, Liu, Dapeng, Zhang, Yufu, Cui, Lunbiao, Shen, Jinjin, Zhu, Fengcai, Bao, Changjun
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2019
• Subjects: Analysis; Epidemiology; Health aspects; Livestock; Major; Plains; Thrombocytopenia; Tick-borne diseases; China; Human-to-human transmission; Severe fever with thrombocytopenia syndrome (SFTS); Endemic region; Bunyavirus
• ISSN: 2328-8957; 2328-8957
• DOI: 10.1093/ofid/ofz209

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is a typical tick-borne, natural focal disease. The natural foci of SFTS were considered to exist in hilly and mountainous areas before 2015. A cluster of 3 patients exposed to a patient with a fulminant disease consistent with SFTS occurred from July to August 2015 in Dongtai County, which is characterized by alluvial plains; this prompted investigation. Methods The epidemiological, clinical, and laboratory features of 4 patients in the cluster were analyzed. Serum samples from the indigenous healthy population and native domesticated animals were collected to conduct laboratory tests, along with small wild animals and ticks. Results In 3 secondary case patients, high fever, thrombocytopenia and leukopenia developed within 8–13 days after contact with blood or bloody secretions from the index patient; SFTS was then diagnosed by means of reverse-transcription polymerase chain reaction. Genomic sequencing and analysis of S and L segments of 2 viral strains isolated from 2 secondary case patients showed that they shared 99.8%–99.9% homology in nucleotide sequence. The seroprevalences among indigenous healthy population, native livestock, native poultry, and small wild animals was 0.74%, 17.54%, 6.67%, and 1.12%, respectively. Three questing ticks, 61 feeding ticks, and 178 small wild animals were collected in August 2015. Survey on tick density and seasonal fluctuation in 2016 showed that ticks were active from March to October. All ticks were identified as Haemaphysalis longicornis. Severe fever with thrombocytopenia bunyavirus (SFTSV)–specific RNA was detected in the ticks collected in 2016, and the minimum SFTSV infection rate in these ticks was 0.54% (1 of 185).Wild mammals and ticks collected in August 2015 tested negative for SFTSV-specific RNA. Conclusions Aside from hilly or mountainous area, a coastal plain was identified as the natural foci of SFTSV in Dongtai County, China. The involvement of migration in the evolution of SFTSV might lead to a transregional transmission event of SFTSV. A cluster of patients with severe fever with thrombocytopenia syndrome was identified in Dongtai County from July to August 2015, suggesting that the natural foci of severe fever with thrombocytopenia bunyavirus (SFTSV) are not limited to hilly or mountainous areas. A transregional SFTSV transmission event occurred in the cluster, further evidence of migration in the evolution of SFTSV.