Contributions of Cerebro-Cerebellar Default Mode Connectivity Patterns to Memory Performance in Mild Cognitive Impairment

• Published in: Journal of Alzheimer's disease Vol. 75; no. 2; pp. 633 - 647
• Main Authors: Pagen, Linda H.G., van de Ven, Vincent G., Gronenschild, Ed H.B.M., Priovoulos, Nikos, Verhey, Frans R.J., Jacobs, Heidi I.L.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2020
• Subjects: Aged; Brain Mapping; Cerebellum - diagnostic imaging; Cerebellum - physiopathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Cognition - physiology; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - psychology; Default Mode Network - diagnostic imaging; Default Mode Network - physiopathology; Female; Humans; Magnetic Resonance Imaging; Male; Memory - physiology; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neuropsychological Tests; functional connectivity; resting state functional MRI; Alzheimer’s disease; cerebellum
• ISSN: 1387-2877; 1875-8908
• DOI: 10.3233/JAD-191127

Background: The cerebral default mode network (DMN) can be mapped onto specific regions in the cerebellum, which are specifically vulnerable to atrophy in Alzheimer’s disease (AD) patients. Objective: We set out to determine whether there are specific differences in the interaction between the cerebral and cerebellar DMN in amnestic mild cognitive impairment (aMCI) patients compared to healthy controls using resting-state functional MRI and whether these differences are relevant for memory performance. Methods: Eighteen patients with aMCI were age and education-matched to eighteen older adults and underwent 3T MR-imaging. We performed seed-based functional connectivity analysis between the cerebellar DMN seeds and the cerebral DMN. Results: Our results showed that compared to healthy older adults, aMCI patients showed lower anti-correlation between the cerebellar DMN and several cerebral DMN regions. Additionally, we showed that degradation of the anti-correlation between the cerebellar DMN and the medial frontal cortex is correlated with worse memory performance in aMCI patients. Conclusion: These findings provide evidence that the cerebellar DMN and cerebral DMN are negatively correlated during rest in older individuals, and suggest that the reduced anti-correlated impacts the modulatory role of the cerebellum on cognitive functioning, in particular on the executive component of memory functions in neurodegenerative diseases.