Interactions between long interpregnancy interval and advanced maternal age on neonatal outcomes

• Published in: World journal of pediatrics : WJP Vol. 19; no. 12; pp. 1155 - 1161
• Main Authors: Ma, Yan, Fu, Hua, li, Yang, Bao, Zheng-Rong, Dong, Wen-Bin, Lei, Xiao-Ping
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.12.2023; Sichuan Clinical Research Center for Birth Defects,Luzhou,China%School of Pediatrics,Southwest Medical University.Luzhou,China; Division of Neonatology,Department of Pediatrics,The Affiliated Hospital of Southwest Medical University,Xiaoping Lei,8 Kangcheng Road,Luzhou 646000,China; Department of Perinatology,The Affiliated Hospital of Southwest Medical University,Luzhou,China
• Subjects: Critical Care Medicine; Imaging; Intensive; Maternal and Child Health; Medicine; Medicine & Public Health; Original; Original Article; Pediatric Surgery; Pediatrics; Radiology; Surgery; Maternal age; Preterm birth; Interaction; Low birth weight; Interpregnancy interval
• ISSN: 1708-8569; 1867-0687
• DOI: 10.1007/s12519-023-00728-4

Background After the implementation of the universal two-child policy in China, it was more frequent to have long interpregnancy intervals (IPIs) and advanced maternal age. However, the interactions between long IPIs and advanced maternal age on neonatal outcomes are unknown. Methods The study subjects of this historical cohort study were multiparas with singleton live births between October 1st, 2015, and October 31st, 2020. IPI was defined as the interval between delivery and conception of the subsequent pregnancy. Logistic regression models were used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of the risks of preterm birth (PTB), low birth weight (LBW), small for gestation age, and 1-min Apgar score ≤ 7 in different IPI groups. Relative excess risk due to interaction (RERI) was used to evaluate the additive interaction between long IPIs and advanced maternal age. Results Compared with the 24 ≤ IPI ≤ 59 months group, the long IPI group (IPI ≥ 60 months) was associated with a higher risk of PTB (aOR, 1.27; 95% CI: 1.07–1.50), LBW (aOR, 1.32; 95% CI 1.08–1.61), and one-minute Apgar score ≤ 7 (aOR, 1.46; 95% CI 1.07–1.98). Negative additive interactions (all RERIs < 0) existed between long IPIs and advanced maternal age for these neonatal outcomes. Meanwhile, IPI < 12 months was also associated with PTB (aOR, 1.51; 95% CI 1.13–2.01), LBW (aOR, 1.50; 95% CI 1.09–2.07), and 1-min Apgar score ≤ 7 (aOR, 1.93; 95% CI 1.23–3.04). Conclusions Both short and long IPIs are associated with an increased risk of adverse neonatal outcomes. Appropriate IPI should be recommended to women planning to become pregnant again. In addition, better antenatal care might be taken to balance the inferiority of advanced maternal age and to improve neonatal outcomes.