Bullous pemphigoid mimicking bullous erythema multiforme: An untoward side effect of penicillins

Three young and middle-aged patients developed severe bullous eruption after receiving various penicillins. The clinical findings included high fever, prostration, widespread bullous eruption mainly on the head, face, and extremities, targetlike lesions on the palms and soles, and severe erosions in...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 18; no. 2; pp. 345 - 349
Main Authors Alcalay, Joseph, David, Michael, Ingber, Arie, Hazaz, Bilha, Sandbank, Miriam
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.02.1988
Elsevier
Subjects
Adolescent
Adult
Amoxicillin - adverse effects
Biological and medical sciences
Diagnosis, Differential
Drug Eruptions - diagnosis
Drug toxicity and drugs side effects treatment
Erythema Multiforme - diagnosis
Female
Humans
Male
Medical sciences
Middle Aged
Pemphigoid, Bullous - chemically induced
Pemphigoid, Bullous - diagnosis
Penicillin G - adverse effects
Penicillin G Procaine - adverse effects
Penicillin V - adverse effects
Pharmacology. Drug treatments
Skin Diseases, Vesiculobullous - chemically induced
Toxicity: skin, dermoskeleton
Bullous dermatosis
Human
Penicillin derivatives
Antibiotic
Skin disease
Toxicity
Bullous pemphigoid
Erythema multiform
Complication
Differential diagnostic
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Summary:Three young and middle-aged patients developed severe bullous eruption after receiving various penicillins. The clinical findings included high fever, prostration, widespread bullous eruption mainly on the head, face, and extremities, targetlike lesions on the palms and soles, and severe erosions in almost all the mucous membranes. Direct and indirect immunofluorescence studies were those of bullous pemphigoid. Complete clearing of the eruption occurred with prednisone therapy. We conclude that drug-induced bullous pemphigoid is a different entity from the classic bullous pemphigoid.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(88)70050-X