Imaging performance in guiding response to neoadjuvant therapy according to breast cancer subtypes: A systematic literature review

• Published in: Critical reviews in oncology/hematology Vol. 112; pp. 198 - 207
• Main Authors: Lindenberg, Melanie A, Miquel-Cases, Anna, Retèl, Valesca P, Sonke, Gabe S, Wesseling, Jelle, Stokkel, Marcel P.M, van Harten, Wim H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2017
• Subjects: Antineoplastic Agents - therapeutic use; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Chemotherapy, Adjuvant; Diagnostic Imaging - methods; Female; Hematology, Oncology and Palliative Medicine; HER2; Humans; Imaging; Neoadjuvant therapy; Neoadjuvant Therapy - methods; Therapeutic response; Treatment Outcome; BC; Neoadjuvant therapy; PR; ERO; DCE-MRI; MRI; FN; FP; Progesterone receptor; AUC; Quality Assessment of Diagnostic Accuracy Studies; Therapeutic response; True positive; Receiver Operating Curve; NPV; False negative; Imaging; PPV; Pathologic complete response; TNBC; Ultrasound; Triple negative breast cancer; pCR; US; Dynamic contrast-enhanced magnetic resonance imaging; DW-MRI; False positive; estrogen receptor; Area Under the Curve; Negative predictive value; ROC; True negative; Neoadjuvant Chemotherapy; Breast Cancer; ER; Physical examination; Positron Emission Tomography Computed Tomography; NAC; Magnetic resonance imaging; PE; Diffusion-weighted magnetic resonance imaging; PET/CT; Positive predictive value; TN; HER2; TP; QUADAS; Human Epidermal growth factor 2; Breast cancer
• ISSN: 1040-8428; 1879-0461
• DOI: 10.1016/j.critrevonc.2017.02.014

Highlights • 15 observational studies examined imaging performance for measuring response during NAC. • Evidence to conclude on the preferred imaging technique per BC subtype is lacking. •18 FDG-PET/CT seems to be preferred in ER-negative/HER2positive BC over MRI. • MRI and18 FDG-PET/CT are promising in both triple negative and HER2-positive BC. • Consensus should be reached on: interval time, cut-off values, and pCR definitions.