Epigenetic gene silencing in the Wnt pathway in breast cancer
Breast cancer is one of the most common malignancies in women. Despite advances in treatment of endocrine-dependent tumors, the complete molecular basis of transformation is still unknown. What is clear is that a variety of genetic lesions and epigenetic modifications are present in the neoplasm. Di...
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Published in | Epigenetics Vol. 3; no. 2; pp. 59 - 63 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
01.03.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Breast cancer is one of the most common malignancies in women. Despite advances in treatment of endocrine-dependent tumors, the complete molecular basis of transformation is still unknown. What is clear is that a variety of genetic lesions and epigenetic modifications are present in the neoplasm. Disregulation of several signaling pathways is known to be associated with breast cancer development, among them is the wingless and integration site growth factor (Wnt) pathway. While genetic mutations of certain components of this pathway, such as APC, are significant contributing factors for colorectal cancers, they are typically not the predominate mechanism associated with breast cancer. Instead, it appears that DNA hypermethylation leads to aberrant regulation of the Wnt pathway in breast cancer, and as such, this review focuses on the epigenetic regulation of Wnt pathway components in breast cancer. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 Present address: National Institute of Standards and Technology; Gaithersburg, Maryland USA |
ISSN: | 1559-2294 1559-2308 |
DOI: | 10.4161/epi.3.2.5899 |