Associations among pericolonic fat, visceral fat, and colorectal polyps on CT colonography
ABSTRACT Objective To determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC). Methods A total of 1169 patients who underwent CTC and optical colonoscopy on the same day were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Vi...
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Published in | Obesity (Silver Spring, Md.) Vol. 23; no. 2; pp. 408 - 414 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.02.2015
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Subjects | |
Online Access | Get full text |
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Summary: | ABSTRACT
Objective
To determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC).
Methods
A total of 1169 patients who underwent CTC and optical colonoscopy on the same day were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue volume was measured at the L2‐L3 levels. Student's t‐tests, odds ratio, logistic regression, binomial statistics, and weighted kappa were performed to ascertain associations with the incidence of colorectal polyps.
Results
Pericolonic fat volume fractions (PFVF) were 61.5 ± 11.0% versus 58.1 ± 11.5%, 61.6 ± 11.1% versus 58.7 ± 11.5%, and 62.4 ± 10.6% versus 58.8 ± 11.5% for patients with and without any polyps, adenomatous polyps, and hyperplastic polyps, respectively (P < 0.0001). Similar trends were observed when examining visceral fat volume fractions (VFVF). When patients were ordered by quintiles of PFVF or VFVF, there were 2.49‐, 2.19‐, and 2.39‐fold increases in odds ratio for the presence of any polyp, adenomatous polyps, or hyperplastic polyps from the first to the fifth quintile for PFVF and 1.92‐, 2.00‐, and 1.71‐fold increases in odds ratio for VFVF. Polyps tended to occur more commonly in parts of the colon that had more PFVF than the spatially adjusted average for patients in the highest quintile of VFVF.
Conclusions
Pericolonic fat accumulations, like visceral fat, are correlated with an increased risk of adenomatous and hyperplastic polyps. |
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Bibliography: | Summers and Yao have pending and/or awarded patents for related automated analyses for CT colonography. Summers and Yao also receive royalty income for a patent license from iCAD. Summers' laboratory receives research support from iCAD. Pickhardt is a consultant for Mindways and Braintree and cofounder of VirtuoCTC. Pickhardt also is on the medical advisory board of Viatronix, Inc. Choi is on the medical advisory boards of Viatronix, Inc., and QI and has received research support from E‐Z‐EM. Disclosure Funding agencies Intramural Research Program of the National Institutes of Health, Clinical Center. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1930-7381 1930-739X |
DOI: | 10.1002/oby.20987 |