Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV

• Published in: Annals of neurology Vol. 54; no. 4; pp. 459 - 463
• Main Authors: Burgoon, Mark P., Hammack, Barbara N., Owens, Gregory P., Maybach, Amy L., Eikelenboom, M. Judith, Gilden, Donald H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2003; Willey-Liss
• Subjects: Aged; Biological and medical sciences; Central Nervous System Infections - cerebrospinal fluid; Central Nervous System Infections - immunology; Central Nervous System Infections - virology; Enzyme-Linked Immunosorbent Assay - methods; Herpes Zoster - immunology; Herpesvirus 3, Human - immunology; Herpesvirus 3, Human - isolation & purification; Human viral diseases; Humans; Immunoglobulins - cerebrospinal fluid; Infectious diseases; Male; Medical sciences; Oligoclonal Bands; Subacute Sclerosing Panencephalitis - cerebrospinal fluid; Subacute Sclerosing Panencephalitis - immunology; Vascular Diseases - cerebrospinal fluid; Vascular Diseases - immunology; Vascular Diseases - virology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral diseases of the nervous system; Human; Varicella zoster virus; Oligoclonal immunoglobulin; Herpesviridae; Alphaherpesvirinae; Central nervous system; IgG; Cerebrospinal fluid; Inflammatory disease; Virus; Infection; Viral disease; Central nervous system disease; Varicella
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.10685

Limited analyses of cerebrospinal fluid from patients with central nervous system infections have shown that the oligoclonal IgG is antibody directed against the agent that causes disease. Using a new method involving binding of IgG to beads coated with lysates prepared from candidate infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with chronic varicella zoster virus vasculopathy is directed against the causative virus. This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause.