Platensimycin, a New Antibiotic and "Superbug Challenger" from Nature

Natural products have once again proven their value as guideposts for unexplored targets. “Old‐fashioned” extract screening integrated into an innovative assay set‐up has opened a new playground for medicinal chemists. Platensimycin is the first member of a novel class of antibiotics that acts throu...

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Bibliographic Details
Published inChemMedChem Vol. 1; no. 9; pp. 951 - 954
Main Authors Häbich, Dieter, von Nussbaum, Franz
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.09.2006
WILEY‐VCH Verlag
Subjects
Adamantane - pharmacology
Aminobenzoates - pharmacology
Anilides - pharmacology
Anti-Bacterial Agents - pharmacology
antibiotics
Bacteria - drug effects
Bacteria - metabolism
biosynthesis
Drug Resistance, Bacterial
fatty acids
Fatty Acids - biosynthesis
natural products
RNA Interference
Structure-Activity Relationship
terpenoids
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Summary:Natural products have once again proven their value as guideposts for unexplored targets. “Old‐fashioned” extract screening integrated into an innovative assay set‐up has opened a new playground for medicinal chemists. Platensimycin is the first member of a novel class of antibiotics that acts through a clinically unexploited target.
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ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200600145