Periodontitis is associated with an increased risk for proximal colorectal neoplasms

• Published in: Scientific reports Vol. 9; no. 1; pp. 7528 - 9
• Main Authors: Kim, Gun Woo, Kim, Young-Sang, Lee, Soo Hyun, Park, Seung Geon, Kim, Duk Hwan, Cho, Joo Young, Hahm, Ki Baik, Hong, Sung Pyo, Yoo, Jun-Hwan
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.05.2019; Nature Publishing Group UK
• Subjects: Adult; Colon; Colonoscopy; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Colorectal Neoplasms - pathology; Cross-Sectional Studies; Female; Gum disease; Health risk assessment; Humans; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oral Health; Periodontitis; Periodontitis - complications; Periodontitis - epidemiology; Prevalence; Republic of Korea - epidemiology; Retrospective Studies; Risk Factors; Smoking; Smoking - adverse effects; Teeth; Triglycerides; Tumors; Republic of Korea
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-44014-8

Interval colorectal cancers detected after colonoscopy are known to be highly associated with proximal colorectal neoplasms (CRNs). This cross-sectional study investigated whether periodontitis could be a risk factor for proximal CRNs in healthy individuals. A total of 2504 subjects who received a colonoscopy and dental exam were enrolled in this study. We divided the subjects into the periodontitis group (n = 216) and the control group (n = 2288). The periodontitis group was defined as subjects who had one or more teeth with a probing pocket depth (PPD) ≥4 mm. The prevalence of proximal CRNs was significantly higher in the periodontitis group (25.0%) than in the control group (12.3%) (P < 0.001). Independent risk factors for proximal CRNs in the multivariate analysis were periodontitis, smoking, age, waist circumference, and triglycerides, and those for proximal advanced CRNs were periodontitis, age, and family history of CRC. However, periodontitis was not a risk factor for overall CRNs and advanced CRNs. Periodontitis was associated with an increased risk of proximal CRNs (odds ratio [OR], 1.525; 95% confidence intervals [95% CI], 1.071-2.172) and proximal advanced CRNs (OR, 2.671; 95% CI, 1.088-6.560). Periodontitis might be associated with proximal CRNs and proximal advanced CRNs.