Current and Future Development in Lung Cancer Diagnosis

Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, espec...

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Published inInternational journal of molecular sciences Vol. 22; no. 16; p. 8661
Main Authors Nooreldeen, Reem, Bach, Horacio
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.08.2021
MDPI
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Abstract Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, especially in screening high-risk populations, such as smokers, exposure to fumes, oil fields, toxic occupational places, etc. Based on the current knowledge, it looks that there is an urgent need to identify novel biomarkers. The current diagnosis of lung cancer includes different types of imaging complemented with pathological assessment of biopsies, but these techniques can still not detect early lung cancer developments. In this review, we described the advantages and disadvantages of current methods used in diagnosing lung cancer, and we provide an analysis of the potential use of body fluids as carriers of biomarkers as predictors of cancer development and progression.
AbstractList Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, especially in screening high-risk populations, such as smokers, exposure to fumes, oil fields, toxic occupational places, etc. Based on the current knowledge, it looks that there is an urgent need to identify novel biomarkers. The current diagnosis of lung cancer includes different types of imaging complemented with pathological assessment of biopsies, but these techniques can still not detect early lung cancer developments. In this review, we described the advantages and disadvantages of current methods used in diagnosing lung cancer, and we provide an analysis of the potential use of body fluids as carriers of biomarkers as predictors of cancer development and progression.
Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, especially in screening high-risk populations, such as smokers, exposure to fumes, oil fields, toxic occupational places, etc. Based on the current knowledge, it looks that there is an urgent need to identify novel biomarkers. The current diagnosis of lung cancer includes different types of imaging complemented with pathological assessment of biopsies, but these techniques can still not detect early lung cancer developments. In this review, we described the advantages and disadvantages of current methods used in diagnosing lung cancer, and we provide an analysis of the potential use of body fluids as carriers of biomarkers as predictors of cancer development and progression.Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, especially in screening high-risk populations, such as smokers, exposure to fumes, oil fields, toxic occupational places, etc. Based on the current knowledge, it looks that there is an urgent need to identify novel biomarkers. The current diagnosis of lung cancer includes different types of imaging complemented with pathological assessment of biopsies, but these techniques can still not detect early lung cancer developments. In this review, we described the advantages and disadvantages of current methods used in diagnosing lung cancer, and we provide an analysis of the potential use of body fluids as carriers of biomarkers as predictors of cancer development and progression.
Author Nooreldeen, Reem
Bach, Horacio
AuthorAffiliation Division of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada; reemnooreldeen@gmail.com
AuthorAffiliation_xml – name: Division of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada; reemnooreldeen@gmail.com
Author_xml – sequence: 1
  givenname: Reem
  surname: Nooreldeen
  fullname: Nooreldeen, Reem
– sequence: 2
  givenname: Horacio
  orcidid: 0000-0002-7740-9299
  surname: Bach
  fullname: Bach, Horacio
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34445366$$D View this record in MEDLINE/PubMed
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body fluids
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biomarkers
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Snippet Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the...
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SubjectTerms Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biopsy
Cancer therapies
Chemotherapy
Diagnostic Imaging
Disease Progression
Early Detection of Cancer
Gene amplification
Humans
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lymphatic system
Medical prognosis
Medical screening
Metastasis
Mutation
Occupational Diseases - diagnosis
Occupational Diseases - etiology
Radiation
Review
Risk Factors
Smoking - adverse effects
Smoking - epidemiology
Tumors
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Title Current and Future Development in Lung Cancer Diagnosis
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