Micro/nanomotors towards in vivo application: cell, tissue and biofluid
Inspired by highly efficient natural motors, synthetic micro/nanomotors are self-propelled machines capable of converting the supplied fuel into mechanical motion. A significant advance has been made in the construction of diverse motors over the last decade. These synthetic motor systems, with rapi...
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| Published in | Chemical Society reviews Vol. 46; no. 17; pp. 5289 - 531 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
29.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Inspired by highly efficient natural motors, synthetic micro/nanomotors are self-propelled machines capable of converting the supplied fuel into mechanical motion. A significant advance has been made in the construction of diverse motors over the last decade. These synthetic motor systems, with rapid transporting and efficient cargo towing abilities, are expected to open up new horizons for various applications. Utilizing emergent motor platforms for
in vivo
applications is one important aspect receiving growing interest as conventional therapeutic methodology still remains limited for cancer, heart, or vasculature diseases. In this review we will highlight the recent efforts towards realistic
in vivo
application of various motor systems. With ever booming research enthusiasm in this field and increasing multidisciplinary cooperation, micro/nanomotors with integrated multifunctionality and selectivity are on their way to revolutionize clinical practice.
This review summarizes recent progress in micro/nanomotors towards
in vivo
applications at cell, tissue and biofluid levels. |
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| Bibliography: | Yingfeng Tu received his BSc Degree in Pharmacy from Wenzhou Medical University, China, in 2010 and a master's degree in Pharmaceutical Science from Peking University in 2013. During his master's program, he focused on drug delivery systems targeting brain tumors using multifunctional liposomal formulations. Currently he is a PhD candidate in the Department of Bio-organic Chemistry at Radboud University, The Netherlands. His research is focused on self-propelled supramolecular motors with stimuli responsive valves for movement control and novel drug delivery. Fei Peng obtained her master's degree from the Health Science Center, Peking University, China, in 2013. During her master's program (2010-2013), she carried out research on poly(amidoamine) dendrimers as multifunctional drug delivery systems. She is now a PhD candidate at the Department of Bio-organic Chemistry, Radboud University, The Netherlands. Her research interests concern self-guided supramolecular polymeric nanomotors for drug delivery. Daniela A. Wilson received her PhD degree with "summa cum laudae" from the "Gh. Asachi" Technical University of Iasi, Romania. After two postdoctoral positions at the University of Pennsylvania, Philadelphia, USA, and Radboud University Nijmegen, The Netherlands, she is currently a full professor at the same institute and the head of the Bio-organic Chemistry Department. Her research interests span a broad range of topics at the interface of supramolecular chemistry, macromolecular chemistry, and nanotechnology. Her current focus is on the design of intelligent, self-propelled and self-guided supramolecular assemblies as the next generation nano-engineered delivery systems. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c6cs00885b |