Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

• Published in: International journal of molecular sciences Vol. 22; no. 14; p. 7499
• Main Authors: Leyton, Benjamin, Ramos, Juliana Nunes, Baio, Paulo Victor Pereira, Veras, João Flávio Carneiro, Souza, Cassius, Burkovski, Andreas, Mattos-Guaraldi, Ana Luíza, Vieira, Verônica Viana, Abanto Marin, Michel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2021; MDPI
• Subjects: Aminoglycosides; Anti-Bacterial Agents - pharmacology; Antimicrobial resistance; Corynebacterium - drug effects; Corynebacterium - genetics; Corynebacterium Infections - drug therapy; Corynebacterium Infections - genetics; Corynebacterium Infections - microbiology; Corynebacterium striatum; Daptomycin; Drug resistance; Drug Resistance, Multiple, Bacterial - genetics; Epidemiology; Fluoroquinolones; Gene expression; Genes; Genomics; Hospitals; Humans; Insertion sequences; Interspersed Repetitive Sequences; Medical equipment; Microbiota; MLS phenotype; Multidrug resistance; multidrug resistance mechanisms; Multidrug resistant organisms; Mutation; Nosocomial infections; Opportunist infection; Pathogens; Plasmids; Review; Tetracyclines; Tn5432; Transposons; β-Lactam antibiotics; Brazil; multidrug resistance mechanisms; pTP10 plasmid; Tn5432; insertion sequences; resistome; transposons; antibiotic resistance genes; Corynebacterium striatum; MLS phenotype; emerging pathogen
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22147499

, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in . This review updates global information related to antimicrobial resistance found in and highlights the essential genomic aspects in its persistence and dissemination. The resistome of comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.