A role for mRNA trafficking and localized translation in peroxisome biogenesis and function?

• Published in: Biochimica et biophysica acta Vol. 1863; no. 5; pp. 911 - 921
• Main Authors: Haimovich, Gal, Cohen-Zontag, Osnat, Gerst, Jeffrey E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2016
• Subjects: Animals; Biological Transport; Endoplasmic reticulum; Endoplasmic Reticulum - chemistry; Endoplasmic Reticulum - metabolism; Eukaryotic Cells - chemistry; Eukaryotic Cells - metabolism; Gene Expression Regulation; Humans; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; MRNA trafficking; Mutation; Organelle Biogenesis; Peroxisome targeting signal; Peroxisomes; Peroxisomes - chemistry; Peroxisomes - metabolism; PEX genes; Plants - chemistry; Plants - metabolism; Protein Isoforms - chemistry; Protein Isoforms - genetics; Protein Isoforms - metabolism; Protein Sorting Signals; Protein translocation; RNA, Messenger - genetics; RNA, Messenger - metabolism; Saccharomyces cerevisiae - chemistry; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Signal Transduction; PEX; ChIP; RaPID; MTS; PTS; CLIP; SNARE; PEX genes; SRP; Protein translocation; UTR; NLS; RNA-seq; MFP; RT-qPCR; Peroxisome targeting signal; ISH; PUF; RBP; TMD; SILAC; mPP; smFISH; ER; MRNA trafficking; PMP; Peroxisomes; TOM; GET; FISH; Endoplasmic reticulum
• ISSN: 0167-4889; 0006-3002; 1879-2596
• DOI: 10.1016/j.bbamcr.2015.09.007

Peroxisomes are distinct membrane-enclosed organelles involved in the β-oxidation of fatty acids and synthesis of ether phospholipids (e.g. plasmalogens), as well as cholesterol and its derivatives (e.g. bile acids). Peroxisomes comprise a distinct and highly segregated subset of cellular proteins, including those of the peroxisome membrane and the interior matrix, and while the mechanisms of protein import into peroxisomes have been extensively studied, they are not fully understood. Here we will examine the potential role of RNA trafficking and localized translation on protein import into peroxisomes and its role in peroxisome biogenesis and function. Given that RNAs encoding peroxisome biogenesis (PEX) and matrix proteins have been found in association with the endoplasmic reticulum and peroxisomes, it suggests that localized translation may play a significant role in the import pathways of these different peroxisomal constituents. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. [Display omitted] •RNA trafficking to peroxisomes and mechanisms of protein import•RNA trafficking to ER and membrane protein import to peroxisomes•Profiling of ER-bound ribosomes and RNAs coding for peroxisome membrane proteins•Translational control and the targeting of RNAs encoding peroxisomal proteins.