Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches
Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There i...
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| Published in | International journal of molecular sciences Vol. 22; no. 8; p. 3850 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
08.04.2021
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms22083850 |
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| Abstract | Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications. |
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| AbstractList | Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications.Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications. Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications. |
| Author | Medina-Leyte, Diana Jhoseline Zepeda-García, Oscar Domínguez-Pérez, Mayra Villarreal-Molina, Teresa Jacobo-Albavera, Leonor González-Garrido, Antonia |
| AuthorAffiliation | 2 Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México (UNAM), Coyoacán, Mexico City 04510, Mexico 1 Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico; dianajhos18@gmail.com (D.J.M.-L.); oscar.zega@gmail.com (O.Z.-G.); mdominguez@inmegen.gob.mx (M.D.-P.); gonzalezg.antonia@gmail.com (A.G.-G.); mvillareal@inmegen.gob.mx (T.V.-M.) |
| AuthorAffiliation_xml | – name: 1 Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico; dianajhos18@gmail.com (D.J.M.-L.); oscar.zega@gmail.com (O.Z.-G.); mdominguez@inmegen.gob.mx (M.D.-P.); gonzalezg.antonia@gmail.com (A.G.-G.); mvillareal@inmegen.gob.mx (T.V.-M.) – name: 2 Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México (UNAM), Coyoacán, Mexico City 04510, Mexico |
| Author_xml | – sequence: 1 givenname: Diana Jhoseline orcidid: 0000-0003-1620-9928 surname: Medina-Leyte fullname: Medina-Leyte, Diana Jhoseline – sequence: 2 givenname: Oscar orcidid: 0000-0002-7436-6887 surname: Zepeda-García fullname: Zepeda-García, Oscar – sequence: 3 givenname: Mayra orcidid: 0000-0002-6049-0430 surname: Domínguez-Pérez fullname: Domínguez-Pérez, Mayra – sequence: 4 givenname: Antonia orcidid: 0000-0003-2578-3155 surname: González-Garrido fullname: González-Garrido, Antonia – sequence: 5 givenname: Teresa orcidid: 0000-0003-4450-7690 surname: Villarreal-Molina fullname: Villarreal-Molina, Teresa – sequence: 6 givenname: Leonor orcidid: 0000-0001-5129-8108 surname: Jacobo-Albavera fullname: Jacobo-Albavera, Leonor |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33917744$$D View this record in MEDLINE/PubMed |
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| Snippet | Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are... |
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| SubjectTerms | Animals Anticoagulants Atherosclerosis Autophagy Binding sites Bioavailability Biomarkers Capillary Permeability Cardiovascular disease Coronary Artery Disease - drug therapy Coronary Artery Disease - etiology Coronary Artery Disease - metabolism Coronary Artery Disease - physiopathology Coronary vessels Cytokines Disease Management Disease prevention Disease Susceptibility Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Hemostasis Homeostasis Humans Inflammation Molecular Targeted Therapy - methods Oxidative stress Pathogenesis Pathophysiology Proteins Review Risk factors Shear stress Thrombosis Vasculitis - drug therapy Vasculitis - etiology Vasculitis - metabolism Vasculitis - physiopathology |
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| Title | Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches |
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